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Duced CD55 promotes T-cell proliferation and Th1 cytokine expression. In addition to C3 production, APCs cleave C3 leading to autocrine and paracrine C3R signaling. C3R signaling promotes MHC class II expression, IL-12 production and B7 co-stimulatory molecules. Dendritic cells that fail to express C3aR suffer reduced T-cell activation. Anaphylatoxins are well known initiators of inflammation but
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Essor of Physiology, Faculty of Science, Ain Shams University for his kind support and guidance throughout this work and for providing the necessary funding and laboratory facilities.20. 21. 22.Tong et al. BMC Endocrine Disorders 2010, 10:4 ARTICLEOpen AccessEarly limited nitrosamine exposures exacerbate high fat diet-mediated type 2 diabete
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